Journal of Cataract & Refractive Surgery
Volume 30, Issue 10 , Pages 2200-2206 , October 2004

Effect of exogenous keratinocyte growth factor on corneal epithelial migration after photorefractive keratectomy

  • Madhavan S. Rajan, MRCOphth,FRCS

      Affiliations

    • Corresponding Author InformationReprint requests to Mr. Madhavan S. Rajan, MRCOphth, FRCS, Department of Ophthalmology, Rayne Institute, St. Thomas' Hospital, London SE17EH, United Kingdom.
    • Departments of Ophthalmology, Rayne Institute, St. Thomas' Hospital, London, United Kingdom
  • ,
  • Shahram Shafiei, MD

      Affiliations

    • St. Erick's Eye Hospital, Regensburg, Germany
  • ,
  • Christoph V.W. Mohrenfels, MD

      Affiliations

    • Stockholm, Sweden, and the University of Regensburg, Regensburg, Germany
  • ,
  • Ann Patmore

      Affiliations

    • Departments of Ophthalmology, Rayne Institute, St. Thomas' Hospital, London, United Kingdom
  • ,
  • Chris Lohmann, MD,PhD

      Affiliations

    • Stockholm, Sweden, and the University of Regensburg, Regensburg, Germany
  • ,
  • John Marshall, PhD

      Affiliations

    • Departments of Ophthalmology, Rayne Institute, St. Thomas' Hospital, London, United Kingdom
  • ,
  • Helene Hamberg-Nystrom, MD,PhD

      Affiliations

    • St. Erick's Eye Hospital, Regensburg, Germany

,Accepted 4 February 2004.

References 

  1. Gartry DS, Kerr Muir MG, Marshall J. Photorefractive keratectomy with an argon fluoride excimer laser (a clinical study). Refract Corneal Surg. 1991;7:420–435
  2. Gartry DS, Kerr Muir MG, Marshall J. Excimer laser photorefractive keratectomy. 18 month follow-up. Ophthalmology. 1992;99:1209–1219
  3. Applegate RA, Marcos S, Thibos LN. Aberrometry (clinical and research applications). Optom Vis Sci. 2003;80:85–86 [editorial]
  4. Fiore T, Carones F, Brancato R. Broad beam vs flying spot excimer laser (refractive and videokeratographic outcomes of two different ablation profiles after photorefractive keratectomy). J Refract Surg. 2001;17:534–541
  5. Manns F, Ho A, Parel J-M, Culbertson W. Ablation profiles for wavefront-guided correction of myopia and primary spherical aberration. J Cataract Refract Surg. 2002;28:766–774
  6. Gartry DS, Larkin DFP, Hill AR, et al.  Retreatment for significant regression after excimer laser photorefractive keratectomy; a prospective, randomized, masked trial. Ophthalmology. 1998;105:131–141
  7. Stephenson CG, Gartry DS, O'Brart DPS, et al.  Photorefractive keratectomy; a 6-year follow-up study. Ophthalmology. 1998;105:273–281
  8. Wilson SE, Liu JJ, Mohan RR. Stromal-epithelial interactions in the cornea. Prog Retin Eye Res. 1999;18:293–309
  9. Baldwin HC, Marshall J. Growth factors in corneal wound healing following refractive surgery (a review). Acta Ophthalmol Scand. 2002;80:238–247
  10. Li D-Q, Tseng SCG. Three patterns of cytokine expression potentially involved in epithelial-fibroblast interactions of human ocular surface. J Cell Physiol. 1995;163:61–79
  11. Wilson SE, Walker JW, Chwang EL, He Y-G. Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea. Invest Ophthalmol Vis Sci. 1993;34:2544–2561
  12. Wilson SE, He Y-G, Weng J, et al. Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor on proliferation, motility and differentiation of human corneal epithelial cells. Exp Eye Res 1994; 59:665–578
  13. Wilson SE, Liang Q, Kim WJ. Lacrimal gland HGF, KGF, and EGF mRNA levels increase after corneal epithelial wounding. Invest Ophthalmol Vis Sci. 1999;40:2185–2190
  14. Wilson SE, Chen L, Mohan RR, et al.  Expression of HGF, KGF, EGF and receptor messenger RNAs following corneal epithelial wounding. Exp Eye Res. 1999;68:377–397
  15. Sotozono C, Kinoshita S, Kita M, Imanishi J. Paracrine role of keratinocyte growth factor in rabbit corneal epithelial cell growth. Exp Eye Res. 1994;59:385–391
  16. Sotozono C, Kinoshita S, Kita M, Imanishi J. Expression of keratinocyte growth factor mRNA in ex vivo and in vitro specimens of human cornea and conjunctiva. Jpn J Ophthalmol. 1994;38:353–359
  17. Sotozono C, Inatomi T, Nakamura M, Kinoshita S. Keratinocyte growth factor accelerates corneal epithelial wound healing in vivo. Invest Ophthalmol Vis Sci. 1995;36:1524–1529
  18. Daniels JT, Khaw PT. Temporal stimulation of corneal fibroblast wound healing activity by differentiating epithelium in vitro. Invest Ophthalmol Vis Sci. 2000;41:3754–3762
  19. Lohmann CP, Gartry DS, Muir MK, et al.  Corneal haze after excimer laser refractive surgery (objective measurements and functional implications). Eur J Ophthalmol. 1991;1:173–180
  20. Lohmann CP, Timberlake GT, Fitzke FW, et al.  Corneal light scattering after excimer laser photorefractive keratectomy (the objective measurements of haze). Refract Corneal Surg. 1992;8:114–121
  21. Liu JJ, Shay JW, Wilson SE. Characterization of a soluble KGF receptor cDNA from human corneal and breast epithelial cells. Invest Ophthalmol Vis Sci. 1998;39:2584–2593
  22. Imanishi J, Kamiyama K, Iguchi I, et al.  Growth factors (importance in wound healing and maintenance of transparency of the cornea). Prog Retin Eye Res. 2000;19:113–129
  23. Barnard JA, Lyons RM, Moses HL. The cell biology of transforming growth factor β. Biochim Biophys Acta. 1990;1032:79–87
  24. Kinoshita S, Adachi W, Sotozono C, et al.  Characteristics of the human ocular surface epithelium. Prog Retin Eye Res. 2001;20:639–673
  25. Hayashi K, Frangieh G, Kenyon KR, et al.  Plasminogen activator activity in vitamin A-deficient rat corneas. Invest Ophthalmol Vis Sci. 1988;29:1810–1819
  26. Hayashi K, Sueishi K. Fibrinolytic activity and species of plasminogen activator in human tears. Exp Eye Res. 1988;46:131–137
  27. Lyons RM, Gentry LE, Purchio AF, Moses HL. Mechanism of activation of latent recombinant transforming growth factor β1 by plasmin. J Cell Biol. 1990;110:1361–1367
  28. Lyons RM, Moses HL. Transforming growth factors and the regulation of cell proliferation. Eur J Biochem. 1990;187:467–473
  29. Corbett MC, Prydal JI, Verma S, et al.  An in vivo investigation of the structures responsible for corneal haze after photorefractive keratectomy and their effect on visual function. Ophthalmology. 1996;103:1366–1380
  30. Møller-Pedersen T, Li HF, Petroll WM, et al.  Confocal microscopic characterization of wound repair after photorefractive keratectomy. Invest Ophthalmol Vis Sci. 1998;39:487–501

 Supported by the Iris Fund for Prevention of Blindness, London, United Kingdom, and St. Erick's Eye Hospital, Stockholm, Sweden.

☆☆ None of the authors has a financial interest in any product mentioned.

 Human Genome Sciences, Inc., Rockville, Maryland, USA, supplied the growth factor for the study.

PII: S0886-3350(04)00166-X

doi: 10.1016/j.jcrs.2004.02.022

Journal of Cataract & Refractive Surgery
Volume 30, Issue 10 , Pages 2200-2206 , October 2004