Journal of Cataract & Refractive Surgery
Volume 30, Issue 11 , Pages 2420-2424 , November 2004

Photochemical keratodesmos as an adjunct to sutures for bonding penetrating keratoplasty corneal incisions

  • Cinthia E. Proano, MD

      Affiliations

    • Massachusetts Eye and Ear Infirmary and the Schepens Eye Research Institute, Massachusetts General Hospital, Boston, MA, USA
    • Wellman Laboratories of Photomedicine, Harvard Medical School, Boston, MA, USA
    • ,
  • Dimitri T. Azar, MD

      Affiliations

    • Corresponding Author InformationReprint requests to Dimitri T. Azar, MD, Director, Corneal and Refractive Surgery Services, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, Massachusetts 02114, USA.
    • Massachusetts Eye and Ear Infirmary and the Schepens Eye Research Institute, Massachusetts General Hospital, Boston, MA, USA
    • ,
  • Mehmet Cem Mocan, MD

      Affiliations

    • Massachusetts Eye and Ear Infirmary and the Schepens Eye Research Institute, Massachusetts General Hospital, Boston, MA, USA
    • ,
  • Robert W. Redmond, PhD

      Affiliations

    • Wellman Laboratories of Photomedicine, Harvard Medical School, Boston, MA, USA
    • ,
  • Irene E. Kochevar, PhD

      Affiliations

    • Wellman Laboratories of Photomedicine, Harvard Medical School, Boston, MA, USA

,Accepted 18 February 2004.

References 

  1. Inoue K, Amano S, Oshika T, Tsuru T. Risk factors for corneal graft failure and rejection in penetrating keratoplasty. Acta Ophthalmol Scand. 2001;79:251–255
  2. Sit M, Weisbrod DJ, Naor J, Slomovic AR. Corneal graft outcome study. Cornea. 2001;20:129–133
  3. Cockerham GC, Bijwaard K, Sheng Z-M, et al.  Primary graft failure; a clinicopathologic and molecular analysis. Ophthalmology. 2000;107:2083–2090 discussion by PR Laibson, 2090–2091
  4. Wilson SE, Kaufman HE. Graft failure after penetrating keratoplasty. Surv Ophthalmol. 1990;34:325–356
  5. Khodadoust AA. The allograft rejection reaction: the leading cause of late failure of clinical corneal grafts. In: Corneal Graft Failure; CIBA Foundation Symposium 15. Amsterdam, Elsevier, 1973; 151–164; discussion, 164–167
  6. Völker-Dieben HJ, D'Amaro J, Kok-van Alphen CC. Hierarchy of prognostic factors for corneal allograft survival. Aust NZ J Ophthalmol. 1987;15:11–18
  7. Shahinian L, Brown SI. Postoperative complications with protruding monofilament nylon sutures. Am J Ophthalmol. 1977;83:546–548
  8. Paque J, Poirier RH. Corneal allograft reaction and its relationship to suture site neovascularization. Ophthalmic Surg. 1977;8(4):71–74
  9. Varley GA, Meisler DM. Complications of penetrating keratoplasty (graft infections). Refract Corneal Surg. 1991;7:62–66
  10. Fong LP, Ormerod LD, Kenyon KR, Foster CS. Microbial keratitis complicating penetrating keratoplasty. Ophthalmology. 1988;95:1269–1275
  11. Gorovoy MS, Stern GA, Hood CI, Allen C. Intrastromal noninflammatory bacterial colonization of a corneal graft. Arch Ophthalmol. 1983;101:1749–1752
  12. Siganos CS, Solomon A, Frucht-Pery J. Microbial findings in suture erosion after penetrating keratoplasty. Ophthalmology. 1997;104:513–516
  13. Leahey AB, Avery RL, Gottsch JD, et al.  Suture abscesses after penetrating keratoplasty. Cornea. 1993;12:489–492
  14. Heaven CJ, Davison CRN, Cockcroft PM. Bacterial contamination of nylon corneal sutures. Eye. 1995;9:116–118
  15. Tseng S-H, Ling K-C. Late microbial keratitis after corneal transplantation. Cornea. 1995;14:591–594
  16. Al-Hazzaa SAF, Tabbara KF. Bacterial keratitis after penetrating keratoplasty. Ophthalmology. 1988;95:1504–1508
  17. Acheson JF, Lyons CJ. Ocular morbidity due to monofilament nylon corneal sutures. Eye. 1991;5:106–112
  18. Lieberman DM. Reply to letter (suture-induced astigmatism). Am Intra-Ocular Implant Soc J. 1981;7:65–66
  19. Cravy TV. Long-term corneal astigmatism related to selected elastic, monofilament, nonabsorbable sutures. J Cataract Refract Surg. 1989;15:61–69
  20. Mulroy L, Kim J, Wu I, et al.  Photochemical keratodesmos for repair of lamellar corneal incisions. Invest Ophthalmol Vis Sci. 2000;41:3335–3340
  21. Gradle HS. The present status of keratoplasty. Am J Ophthalmol. 1921;4:895–899
  22. Khodadoust AA. Tissue adhesives in ophthalmology. In:  Sears ML,  Tarkkanen A editor. Surgical Pharmacology of the Eye. New York, NY: Raven Press; 1985;p. 223–234
  23. Henrick A, Gaster RN, Silverstone PJ. Organic tissue glue in the closure of cataract incisions. J Cataract Refract Surg. 1987;13:551–553
  24. Henrick A, Kalpakian B, Gaster RN, Vanley C. Organic tissue glue in the closure of cataract incisions in rabbit eyes. J Cataract Refract Surg. 1991;17:551–555
  25. Shigemitsu T, Majima Y. The utilization of a biological adhesive for wound treatment (comparison of suture, self-sealing sutureless and cyanoacrylate closure in the tensile strength test). Int Ophthalmol. 1996;20:323–328
  26. Judy MM, Matthews JL, Boriack RL, et al.  Photochemical cross-linking of proteins with visible-light absorbing 1,8-naphthalimides. In:  Jacques SL,  Katzir A editor. Laser-Tissue Interaction IV. Proceedings SPIE 1882. Bellington, WA: SPIE; 1993;p. 305–308
  27. Judy MM, Matthews JL, Boriack RL, et al.  Heat-free photochemical tissue welding with 1,8-naphthalimide dyes using visible (420 nm) light. In:  Shapshay SM,  Anderson RR,  White JV, et al. editor. Lasers in Otolaryngology, Dermatology, and Tissue Welding. Proceedings SPIE 1876. Bellington, WA: SPIE; 1993;p. 175–179
  28. Goins KM, Khadem J, Majmudar PA, Ernest JT. Photodynamic biologic tissue glue to enhance corneal wound healing after radial keratotomy. J Cataract Refract Surg. 1997;23:1331–1338
  29. Goins KM, Khadem J, Majmudar PA. Relative strength of photodynamic biologic tissue glue in penetrating keratoplasty in cadaver eyes. J Cataract Refract Surg. 1998;24:1566–1570
  30. Khadem J, Truong T, Ernest JT. Photodynamic biologic tissue glue. Cornea. 1994;13:406–410
  31. Bass LS, Treat MR. Laser tissue welding (a comprehensive review of current and future clinical applications). Lasers Surg Med. 1995;17:315–349
  32. Schober R, Ulrich F, Sander T, et al.  Laser-induced alteration of collagen substructure allows microsurgical tissue welding. Science. 1986;232:1421–1422
  33. Moreira H, Campos M, Sawusch MR, et al.  Holmium laser thermokeratoplasty. Ophthalmology. 1993;100:752–761

☆ None of the authors has a financial interest in any product mentioned.

☆☆ Supported by the DoD Medical Free Electron Laser Program, contract number F 49620-01-1-0014, and the DoE, contract number DoE-FG02-91ER61228.

PII: S0886-3350(04)00312-8

doi: 10.1016/j.jcrs.2004.02.068

Journal of Cataract & Refractive Surgery
Volume 30, Issue 11 , Pages 2420-2424 , November 2004

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