Journal of Cataract & Refractive Surgery
Volume 31, Issue 11 , Pages 2137-2141 , November 2005

Effect of gatifloxacin 0.3% and moxifloxacin 0.5% ophthalmic solutions on human corneal epithelium following 2 dosing regimens

,Accepted 27 April 2005.

References 

  1. Tipperman R. Pharmacologic considerations for cataract surgery. Curr Opin Ophthalmol. 2004;15:51–55
  2. Noecker R. Effects of common ophthalmic preservatives on ocular health. Adv Ther. 2001;18:205–215
  3. Burstein NL. Corneal cytotoxicity of topically applied drugs, vehicles and preservatives. Surv Ophthalmol. 1980;25:15–30
  4. Ichijima H, Petroll WM, Jester JV, Cavanagh HD. Confocal microscopic studies of living rabbit cornea treated with benzalkonium chloride. Cornea. 1992;11:221–225
  5. Furrer P, Plazonnet B, Mayer JM, Gurny R. Application of in vivo confocal microscopy to the objective evaluation of ocular irritation induced by surfactants. Int J Pharm. 2000;207:89–98
  6. Kim AS, McCulley JP, Cavanagh HD, et al. Evaluation of the effects of topical ophthalmic fluoroquinolones on the cornea using in vivo confocal microscopy. Invest Ophthalmol Vis Sci. 2003;44(E-Abstract):1367
  7. Kovoor TA, Kim AS, McCulley JP, et al. Evaluation of the corneal effects of topical ophthalmic fluoroquinolones using in vivo confocal microscopy. Eye Contact Lens. 2004;30:90–94
  8. Pisella PJ, Pouliquen P, Baudouin C. Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication. Br J Ophthalmol. 2002;86:418–423
  9. Baudouin C. Side effects of antiglaucomatous drugs on the ocular surface. Curr Opin Ophthalmol. 1996;7:80–86
  10. Baudouin C, Pisella PJ, Fillacier K, et al. Ocular surface inflammatory changes induced by topical antiglaucoma drugs: human and animal studies. Ophthalmology. 1999;106:556–563
  11. de Jong C, Stolwijk T, Kuppens E, et al. Topical timolol with and without benzalkonium chloride: epithelial permeability and autofluorescence of the cornea in glaucoma. Graefes Arch Clin Exp Ophthalmol. 1994;232:221–224
  12. Baudouin C, de Lunardo C. Short-term comparative study of topical 2% carteolol with and without benzalkonium chloride in healthy volunteers. Br J Ophthalmol. 1998;82:39–42

 Supported in part by an unrestricted educational grant from Allergan, Inc., and by the Cornea Research Foundation of America.Clorissa Quillin, Laurie Potrzebowski, and Annette Cooke provided technical and logistic assistance with this clinical study.Dr. Maclellan is employed by Nidek, which sells the Confoscan 3 confocal microscope. No other author has a financial or proprietary interest in material or method mentioned.

PII: S0886-3350(05)00680-2

doi: 10.1016/j.jcrs.2005.04.032

Journal of Cataract & Refractive Surgery
Volume 31, Issue 11 , Pages 2137-2141 , November 2005

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