Journal of Cataract & Refractive Surgery
Volume 32, Issue 7 , Pages 1119-1128 , July 2006

Confocal assessment of the corneal response to intracorneal lens insertion and laser in situ keratomileusis with flap creation using IntraLase

,Accepted 2 January 2006.

References 

  1. Binder PS. Flap dimensions created with the IntraLase FS laser. J Cataract Refract Surg. 2004;30:26–32
  2. Sugar A. Ultrafast (femtosecond) laser refractive surgery. Curr Opin Ophthalmol. 2002;13:246–249
  3. Durrie DS, Kezirian GM. Femtosecond laser versus mechanical keratome flaps in wavefront-guided laser in situ keratomileusis; prospective contralateral eye study. J Cataract Refract Surg. 2005;31:120–126
  4. Tran DB, Sarayba MA, Bor Z, et al. Randomized prospective clinical study comparing induced aberrations with IntraLase and Hansatome flap creation in fellow eyes; potential impact on wavefront-guided laser in situ keratomileusis. J Cataract Refract Surg. 2005;31:97–105
  5. Kezirian GM, Stonecipher KG. Comparison of the IntraLase femtosecond laser and mechanical keratomes for laser in situ keratomileusis. J Cataract Refract Surg. 2004;30:804–811
  6. Nordan LT, Slade SG, Baker RN, et al. Femtosecond laser flap creation for laser in situ keratomileusis: six-month follow-up of initial U.S. clinical series. J Refract Surg. 2003;19:8–14
  7. Ismail MM. Correction of hyperopia with intracorneal implants. J Cataract Refract Surg. 2002;28:527–530
  8. Michieletto P, Ligabue E, Balestrazzi A, et al. PermaVision intracorneal lens for the correction of hyperopia. J Cataract Refract Surg. 2004;30:2152–2157
  9. Güell JL, Velasco F, Guerrero E, et al. Confocal microscopy of corneas with an intracorneal lens for hyperopia. J Refract Surg. 2004;20:778–782
  10. Møller-Pedersen T, Cavanagh HD, Petroll WM, Jester JV. Corneal haze development after PRK is regulated by volume of stromal tissue removal. Cornea. 1998;17:627–639
  11. Møller-Pedersen T, Cavanagh HD, Petroll WM, Jester JV. Stromal wound healing explains refractive instability and haze development after photorefractive keratectomy; a 1-year confocal microscopic study. Ophthalmology. 2000;107:1235–1245
  12. Møller-Pedersen T, Li HF, Petroll WM, et al. Confocal microscopic characterization of wound repair after photorefractive keratectomy. Invest Ophthalmol Vis Sci. 1998;39:487–501
  13. Møller-Pedersen T, Vogel M, Li HF, et al. Quantification of stromal thinning, epithelial thickness, and corneal haze after photorefractive keratectomy using in vivo confocal microscopy. Ophthalmology. 1997;104:360–368
  14. Bühren J, Kohnen T. Stromal haze after laser in situ keratomileusis; clinical and confocal microscopy findings. J Cataract Refract Surg. 2003;29:1718–1726
  15. Perez-Gomez I, Efron N. Change to corneal morphology after refractive surgery (myopic laser in situ keratomileusis) as viewed with a confocal microscope. Optom Vis Sci. 2003;80:690–697
  16. Avunduk AM, Senft CJ, Emerah S, et al. Corneal healing after uncomplicated LASIK and its relationship to refractive changes: a six-month prospective confocal study. Invest Ophthalmol Vis Sci. 2004;45:1334–1339
  17. Pisella P-J, Auzerie O, Bokobza Y, et al. Evaluation of corneal stromal changes in vivo after laser in situ keratomileusis with confocal microscopy. Ophthalmology. 2001;108:1744–1750
  18. Mitooka K, Ramirez M, Maguire LJ, et al. Keratocyte density of central human cornea after laser in situ keratomileusis. Am J Ophthalmol. 2002;133:307–314
  19. Erie JC, Nau CB, McLaren JW, et al. Long-term keratocyte deficits in the corneal stroma after LASIK. Ophthalmology. 2004;111:1356–1361
  20. Ivarsen A, Laurberg T, Møller-Pedersen T. Role of keratocyte loss on corneal wound repair after LASIK. Invest Ophthalmol Vis Sci. 2004;45:3499–3506
  21. Vesaluoma M, Pérez-Santonja J, Petroll WM, et al. Corneal stromal changes induced by myopic LASIK. Invest Ophthalmol Vis Sci. 2000;41:369–376erratum 2027
  22. Dawson DG, Holley GP, Geroski DH, et al. Ex vivo confocal microscopy of human LASIK corneas with histologic and ultrastructural correlation. Ophthalmology. 2005;112:634–644
  23. Heisterkamp A, Mamom T, Kermani O, et al. Intrastromal refractive surgery with ultrashort laser pulses: in vivo study on the rabbit eye. Graefes Arch Clin Exp Ophthalmol. 2003;241:511–517
  24. Alió JL, Mulet ME, Zapata LF, et al. Intracorneal inlay complicated by intrastromal epithelial opacification. Arch Ophthalmol. 2004;122:1441–1446
  25. Li HF, Petroll WM, Møller-Pederson T, et al. Epithelial and corneal thickness measurements by in vivo confocal microscopy through focusing (CMTF). Curr Eye Res. 1997;16:214–221
  26. Li J, Jester JV, Cavanagh HD, et al. On-line 3-dimensional confocal imaging in vivo. Invest Ophthalmol Vis Sci. 2000;41:2945–2953
  27. Gokmen F, Jester JV, Petroll WM, et al. In vivo confocal microscopy through-focusing to measure corneal flap thickness after laser in situ keratomileusis. J Cataract Refract Surg. 2002;28:962–970
  28. Erie JC, Patel SV, McLaren JW, et al. Effect of myopic laser in situ keratomileusis on epithelial and stromal thickness; a confocal microscopy study. Ophthalmology. 2002;109:1447–1452
  29. Perez-Gomez I, Efron N. Confocal microscopic evaluation of particles at the corneal flap interface after myopic laser in situ keratomileusis. J Cataract Refract Surg. 2003;29:1373–1377
  30. Ivarsen A, Thøgersen J, Keiding SR, et al. Plastic particles at the LASIK interface. Ophthalmology. 2004;111:18–23
  31. Ivarsen A, Møller-Pedersen T. LASIK induces minimal regrowth and no haze development in rabbit corneas. Curr Eye Res. 2005;30:363–373
  32. Alió JL, Shabayek MH, Montes-Mico R, et al. Intracorneal hydrogel lenses and corneal aberrations. J Refract Surg. 2005;21:247–252

 Presented in part at the ASCRS Symposium on Cataract, IOL and Refractive Surgery, Washington, DC, April 2005; the annual meeting of the Association for Research in Vision Science, Ft. Lauderdale, Florida, USA, May 2005; and the annual meeting of the American Academy of Ophthalmology, Chicago, Illinois, USA, October 2005.Supported in part by NIH grants R01 EY013322 (W.M.P.), departmental infrastructure grant EY016664, a Lew R. Wasserman Merit award (W.M.P.), and an unrestricted grant from Research to Prevent Blindness, Inc.No author has a financial or proprietary interest in any material or method mentioned.

PII: S0886-3350(06)00316-6

doi: 10.1016/j.jcrs.2006.01.093

Journal of Cataract & Refractive Surgery
Volume 32, Issue 7 , Pages 1119-1128 , July 2006