Journal of Cataract & Refractive Surgery
Volume 32, Issue 9 , Pages 1474-1482 , September 2006

Preoperative ketorolac tromethamine 0.4% in phacoemulsification outcomes: Pharmacokinetic-response curve

,Accepted 3 April 2006.

References 

  1. McColgin AZ, Heier JS. Control of intraocular inflammation associated with cataract surgery. Curr Opin Ophthalmol. 2000;11:36
  2. Polansky JR, Weinreb RN. Anti-inflammatory agents: steroids as anti-inflammatory agents. In:  Sears ML editors. Pharmacology of the Eye. New York, NY: Springer-Verlag; 1984;p. 459–538
  3. Quinn CJ. Cystoid macular edema. Optom Clin. 1996;5:111–130
  4. Yannuzzi LA. A perspective on the treatment of aphakic macula edema. Surv Ophthalmol. 1984;28:540–553
  5. Guzek JP, Holm M, Cotter JB, et al. Risk factors for intraoperative complications in 1000 extracapsular cataract cases. Ophthalmology. 1987;94:461–466
  6. Stewart R, Grosserode R, Cheetham JK, Rosenthal A. Efficacy and safety profile of ketorolac 0.5% ophthalmic solution in the prevention of surgically induced miosis during cataract surgery. Clin Ther. 1999;21:723–732
  7. Solomon KD, Donnenfeld ED, Raizman M, et al. Safety and efficacy of ketorolac tromethamine 0.4% ophthalmic solution in post-photorefractive keratectomy patients. J Cataract Refract Surg. 2004;30:1653–1660
  8. Heier J, Cheetham JK, DeGryse R, et al. Ketorolac tromethamine 0.5% ophthalmic solution in the treatment of moderate to severe ocular inflammation after cataract surgery: a randomized, vehicle-controlled clinical trial. Am J Ophthalmol. 1999;127:253–259
  9. Snyder RW, Siekert RW, Schwiegerling J, et al. Acular as a single agent for use as an antimiotic and anti-inflammatory in cataract surgery. J Cataract Refract Surg. 2000;26:1225–1227
  10. Solomon KD, Turkalj JW, Whiteside SB, et al. Topical 0.5% ketorolac vs 0.03% flurbiprofen for inhibition of miosis during cataract surgery. Arch Ophthalmol. 1997;115:1119–1122
  11. Flach AJ, Stegmann RC, Graham J, Kruger LP. Prophylaxis of aphakic cystoid macular edema without corticosteroids. A paired-comparison, placebo-controlled double-masked study. Ophthalmology. 1990;97:1253–1258
  12. Singal N, Hopkins J. Pseudophakic cystoid macular edema: ketorolac alone vs. ketorolac plus prednisolone. Can J Ophthalmol. 2004;39:245–250
  13. Price MO, Price FW. Efficacy of topical ketorolac tromethamine 0.4% for control of pain or discomfort associated with cataract surgery. Curr Med Res Opin. 2004;20:2015–2019

 Presented in part at the ASCRS Symposium on Cataract, IOL and Refractive Surgery, Washington, DC, USA, April 2005.Supported in part by an unrestricted grant from Allergan Inc., Irvine, California, and the Lions Eye Bank for Long Island, Long Island, New York, USA.Drs. Donnenfeld, Perry, and Wittpenn are consultants to Allergan Pharmaceuticals. No other author has a financial or proprietary interest in any material or method mentioned.

PII: S0886-3350(06)00657-2

doi: 10.1016/j.jcrs.2006.04.009

Journal of Cataract & Refractive Surgery
Volume 32, Issue 9 , Pages 1474-1482 , September 2006