Journal of Cataract & Refractive Surgery
Volume 33, Issue 1 , Pages 53-58 , January 2007

Nepafenac ophthalmic suspension 0.1% for the prevention and treatment of ocular inflammation associated with cataract surgery

,Accepted 21 August 2006.

References 

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  2. Flach AJ, Dolan BJ, Donahue ME, et al. Comparative effects of ketorolac 0.5% or diclofenac 0.1% ophthalmic solutions on inflammation after cataract surgery. Ophthalmology. 1998;105:1775–1779
  3. Roberts CW. Pretreatment with topical diclofenac sodium to decrease postoperative inflammation. Ophthalmology. 1996;103:636–639
  4. Simone JN, Whitacre MM. Effects of anti-inflammatory drugs following cataract extraction. Curr Opin Ophthalmol. 2001;12:63–67
  5. Solomon KD, Vroman DT, Barker D, Gehlken J. Comparison of ketorolac tromethamine 0.5% and rimexolone 1% to control inflammation after cataract extraction; prospective randomized double-masked study. J Cataract Refract Surg. 2001;27:1232–1237
  6. Brennan KM, Brown RM, Roberts CW. A comparison of topical non-steroidal anti-inflammatory drugs to steroids for control of post cataract inflammation. Insight J Am Soc Ophthalmic Reg Nurses. 1993;18(1):8–9, 11
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  9. Flach AJ. Topical nonsteroidal antiinflammatory drugs in ophthalmology. Int Ophthalmol Clin. 2002;42(1):1–11
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  11. Solomon KD, Cheetham JK, DeGryse R, et al. Topical ketorolac tromethamine 0.5% ophthalmic solution in ocular inflammation after cataract surgery. Ophthalmology. 2001;108:331–337
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  13. Holzer MP, Solomon KD, Sandoval HP, Vroman DT. Comparison of ketorolac tromethamine 0.5% and loteprednol etabonate 0.5% for inflammation after phacoemulsification; prospective randomized double-masked study. J Cataract Refract Surg. 2002;28:93–99
  14. Roberts CW, Brennan KM. A comparison of topical diclofenac with prednisolone for postcataract inflammation. Arch Ophthalmol. 1995;113:725–727
  15. O'Brien TP. Emerging guidelines for use of NSAID therapy to optimize cataract surgery patient care. Curr Med Res Opin. 2005;21:1131–1137erratum, 1431–1432
  16. Phero JC, Becker DE, Dionne RA. Contemporary trends in acute pain management. Curr Opin Otolaryngol Head Neck Surg. 2004;12:209–216
  17. Gamache DA, Graff G, Brady MT, et al. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. Inflammation. 2000;24:357–370
  18. Ke T-L, Graff G, Spellman JM, Yanni JM. Nepafenac a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers. Inflammation. 2000;24:371–384
  19. Kapin MA, Yanni JM, Brady MT, et al. Inflammation-mediated retinal edema in the rabbit is inhibited by topical nepafenac. Inflammation. 2003;27:281–291

 Presented at the ASCRS Symposium on Cataract, IOL and Refractive Surgery, Washington, D.C., USA, April 2005.Funded by Alcon Research, Ltd., Fort Worth, Texas, USA.No author has a financial or proprietary interest in any method or material mentioned.Louis M. Alpern, MD, Robert J. Arleo, MD, Stephen F. Brint, MD, Mike Caplan, MD, Lisa Marie Cibik, MD, Robert J. Cionni, MD, Peter S. Dawson, MD, Arthur M. Fishman, MD, Gary Foster, MD, Henry M. Haley Jr, MD, Jeffrey D. Horn, MD, Ronald A. Landry, MD, Matthew D. Paul, MD, E. Ronald Salvitti, MD, Stephen V. Scoper, MD, Steven Silverstein, MD, and Jeffrey C. Whitsett, MD, served as fellow investigators.

PII: S0886-3350(06)01213-2

doi: 10.1016/j.jcrs.2006.08.043

Journal of Cataract & Refractive Surgery
Volume 33, Issue 1 , Pages 53-58 , January 2007

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