Journal of Cataract & Refractive Surgery
Volume 33, Issue 9 , Pages 1515-1521 , September 2007

Subbasal nerve fiber regeneration after LASIK and LASEK assessed by noncontact esthesiometry and in vivo confocal microscopy: Prospective study

,Accepted 25 May 2007.

References 

  1. Taneri S, Zieske JD, Azar DT. Evolution, techniques, clinical outcomes, and pathophysiology of LASEK: review of the literature. Surv Ophthalmol. 2004;49:576–602erratum 2005; 50:502–504
  2. Müller LJ, Marfurt CF, Kruse F, Tervo TMT. Corneal nerves: structure, contents and function. Exp Eye Res. 2003;76:521–542errata 2003; 77:253
  3. Dartt DA. Dysfunctional neural regulation of lacrimal gland secretion and its role in the pathogenesis of dry eye syndromes. Ocul Surface. 2004;2:76–91
  4. Pérez-Santonja JJ, Sakla HF, Cardona C, et al. Corneal sensitivity after photorefractive keratectomy and laser in situ keratomileusis for low myopia. Am J Ophthalmol. 1999;127:497–504
  5. Martin XY, Safran AB. Corneal hypoesthesia. Surv Ophthalmol. 1988;33:28–40notes 217
  6. Murphy PJ, Patel S, Marshall J. A new non-contact corneal aesthesiometer (NCCA). Ophthalmic Physiol Opt. 1996;16:101–107
  7. Patel DV, McGhee CNJ. Contemporary in vivo confocal microscopy of the living human cornea using white light and laser scanning techniques: a major review. Clin Exp Ophthalmol. 2007;35:71–88
  8. Szaflik JP. Comparison of in vivo confocal microscopy of human cornea by white light scanning slit and laser scanning systems. Cornea. 2007;26:438–445
  9. Tavakoli M, Kallinikos PA, Efron N, et al. Corneal sensitivity is reduced and relates to the severity of neuropathy in patients with diabetes. Diabetes Care 2007; 30:1895–1897
  10. Malik RA, Kallinikos P, Abbott CA, et al. Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients. Diabetologia. 2003;46:683–688
  11. Murphy PJ, Lawrenson JG, Patel S, Marshall J. Reliability of the non-contact corneal aesthesiometer and its comparison with the Cochet-Bonnet aesthesiometer. Ophthalmic Physiol Opt. 1998;18:532–539
  12. Oliveira-Soto L, Efron N. Morphology of corneal nerves using confocal microscopy. Cornea. 2001;20:374–384
  13. Kallinikos P, Berhanu M, O'Donnell C, et al. Corneal nerve tortuosity in diabetic patients with neuropathy. Invest Ophthalmol Vis Sci. 2004;45:418–422
  14. Grupcheva CN, Wong T, Riley AF, McGhee CNJ. Assessing the sub-basal nerve plexus of the living healthy human cornea by in vivo confocal microscopy. Clin Exp Ophthalmol. 2002;30:187–190
  15. Niederer RL, Perumal D, Sherwin T, McGhee CNJ. Corneal innervation and cellular changes after corneal transplantation: an in vivo confocal microscopy study. Invest Ophthalmol Vis Sci. 2007;48:621–626
  16. Patel S, Pérez-Santonja JJ, Alió JL, Murphy PJ. Corneal sensitivity and some properties of the tear film after laser in situ keratomileusis. J Refract Surg. 2001;17:17–24
  17. De Paiva CS, Pflugfelder SC. Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation. Am J Ophthalmol. 2004;137:109–115
  18. Stapleton F, Hayward KB, Bachand N, et al. Evaluation of corneal sensitivity to mechanical and chemical stimuli after LASIK: a pilot study. Eye Contact Lens. 2006;32:88–93
  19. Chuck RS, Quiros PA, Perez AC, McDonnell PJ. Corneal sensation after laser in situ keratomileusis. J Cataract Refract Surg. 2000;26:337–339
  20. Michaeli A, Slomovic AR, Sakhichand K, Rootman DS. Effect of laser in situ keratomileusis on tear secretion and corneal sensitivity. J Refract Surg. 2004;20:379–383
  21. Linna TU, Vesaluoma MH, Pérez-Santonja JJ, et al. Effect of myopic LASIK on corneal sensitivity and morphology of subbasal nerves. Invest Ophthalmol Vis Sci. 2000;41:393–397
  22. Lee SJ, Kim JK, Seo KY, et al. Comparison of corneal nerve regeneration and sensitivity between LASIK and laser epithelial keratomileusis (LASEK). Am J Ophthalmol. 2006;141:1009–1015
  23. Kumano Y, Matsui H, Zushi I, et al. Recovery of corneal sensation after myopic correction by laser in situ keratomileusis with a nasal or superior hinge. J Cataract Refract Surg. 2003;29:757–761
  24. Bragheeth MA, Dua HS. Corneal sensation after myopic and hyperopic LASIK: clinical and confocal microscopic study. Br J Ophthalmol. 2005;89:580–585
  25. Nejima R, Miyata K, Tanabe T, et al. Corneal barrier function, tear film stability, and corneal sensation after photorefractive keratectomy and laser in situ keratomileusis. Am J Ophthalmol. 2005;139:64–71
  26. Herrmann WA, Shah C, Gabler B, et al. Corneal sensation after laser epithelial keratomileusis for the correction of myopia. Graefes Arch Clin Exp Ophthalmol. 2005;243:33–37
  27. Horwath-Winter J, Vidic B, Schwantzer G, Schmut O. Early changes in corneal sensation, ocular surface integrity, and tear-film function after laser-assisted subepithelial keratectomy. J Cataract Refract Surg. 2004;30:2316–2321
  28. Wu Y, Chu RY, Zhou XT, et al. Recovery of corneal sensitivity after laser-assisted subepithelial keratectomy. J Cataract Refract Surg. 2006;32:785–788
  29. Müller LJ, Vrensen GFJM, Pels L, et al. Architecture of human corneal nerves. Invest Ophthalmol Vis Sci. 1997;38:985–994
  30. Müller LJ, Marfurt CF, Kruse F, Tervo TMT. Corneal nerves: structure, contents and function. Exp Eye Res. 2003;76:521–542errata 2003; 77:253
  31. Perez-Gomez I, Efron N. Change to corneal morphology after refractive surgery (myopic laser in situ keratomileusis) as viewed with a confocal microscope. Optom Vis Sci. 2003;80:690–697
  32. Lee BH, McLaren JW, Erie JC, et al. Reinnervation in the cornea after LASIK. Invest Ophthalmol Vis Sci. 2002;43:3660–3664
  33. Calvillo MP, McLaren JW, Hodge DO, Bourne WM. Corneal reinnervation after LASIK: prospective 3-year longitudinal study. Invest Ophthalmol Vis Sci. 2004;45:3991–3996
  34. Erie JC, McLaren JW, Hodge DO, Bourne WM. Recovery of corneal subbasal nerve density after PRK and LASIK. Am J Ophthalmol. 2005;140:1059–1064
  35. Linna T, Tervo T. Real-time confocal microscopic observations on human corneal nerves and wound healing after excimer laser photorefractive keratectomy. Curr Eye Res. 1997;16:640–649
  36. Frueh BE, Cadez R, Böhnke N. In vivo confocal microscopy after photorefractive keratectomy in humans; a prospective, long-term study. Arch Ophthalmol. 1998;116:1425–1431
  37. Erie JC. Corneal wound healing after photorefractive keratectomy: a 3-year confocal microscopy study. Trans Am Ophthalmol Soc. 2003;101:287–333Available at: http://www.aosonline.org/2001xactions.htmlAccessed June 2, 2007
  38. Kauffmann T, Bodanowitz S, Hesse L, Kroll P. Corneal reinnervation after photorefractive keratectomy and laser in situ keratomileusis: an in vivo study with a confocal videomicroscope. Ger J Ophthalmol 1996/1997; 5:508–512
  39. Wu Y, Chu RY, Zhou XT, et al. [Recovery of corneal sensitivity after laser in situ keratomileusis and laser-assisted subepithelial keratectomy]. [Chinese] Zhonghua Yan Ke Za Zhi. 2005;41:972–976
  40. Patel DV, McGhee CNJ. Mapping of the normal human corneal sub-basal nerve plexus by in vivo laser scanning confocal microscopy. Invest Ophthalmol Vis Sci. 2005;46:4485–4488

 No author has a financial or proprietary interest in any material or method mentioned.

PII: S0886-3350(07)01032-2

doi: 10.1016/j.jcrs.2007.05.023

Journal of Cataract & Refractive Surgery
Volume 33, Issue 9 , Pages 1515-1521 , September 2007

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