Journal of Cataract & Refractive Surgery
Volume 33, Issue 11 , Pages 1925-1929 , November 2007

Ketorolac tromethamine LS 0.4% versus nepafenac 0.1% in patients having cataract surgery: Prospective randomized double-masked clinical trial

,Accepted 3 July 2007.

References 

  1. Price MO, Price FW. Efficacy of topical ketorolac tromethamine 0.4% for control of pain or discomfort associated with cataract surgery. Curr Med Res Opin. 2004;20:2015–2019
  2. Solomon KD, Donnenfeld ED, Raizman M, et al. Safety and efficacy of ketorolac tromethamine 0.4% ophthalmic solution in post-photorefractive keratectomy patients. J Cataract Refract Surg. 2004;30:1653–1660
  3. Lane SS, Modi SS, Lehmann RP, Holland EJ. Nepafenac ophthalmic suspension 0.1% for the prevention and treatment of ocular inflammation associated with cataract surgery. J Cataract Refract Surg. 2007;33:53–58erratum, 563
  4. Colin J, Paquette B. Comparison of the analgesic efficacy and safety of nepafenac ophthalmic suspension compared with diclofenac ophthalmic solution for ocular pain and photophobia after excimer laser surgery: a phase II, randomized, double-masked trial. Clin Ther. 2006;28:527–536
  5. Gamache DA, Graff G, Brady MT, et al. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. Inflammation. 2000;24:357–370
  6. Lindstrom R, Kim T. Ocular permeation and inhibition of retinal inflammation: an examination of data and expert opinion on the clinical utility of nepafenac. Curr Med Res Opin. 2006;22:397–404erratum, 1237
  7. Waterbury LD, Silliman D, Jolas T. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006;22:1133–1140
  8. Donnenfeld ED, Perry HD, Wittpenn JR, et al. Preoperative ketorolac tromethamine 0.4% in phacoemulsification outcomes: pharmacokinetic-response curve. J Cataract Refract Surg. 2006;32:1474–1482
  9. Ong-Tone L. Aqueous humor penetration of gatifloxacin and moxifloxacin eyedrops given by different methods before cataract surgery. J Cataract Refract Surg. 2007;33:59–62
  10. Moshirfar M, Feiz V, Vitale AT, et al. Endophthalmitis after uncomplicated cataract surgery with the use of fourth-generation fluoroquinolones; a retrospective observational case series. Ophthalmology. 2007;114:686–691
  11. Burka JM, Bower KS, VanRoekel RC, et al. The effect of moxifloxacin and gatifloxacin on long-term visual outcomes following photorefractive keratectomy. J Refract Surg. 2007;23:414–417
  12. Samudre SS, Lattanzio FA, Williams PB, Sheppard JD. Comparison of topical steroids for acute anterior uveitis. J Ocul Pharmacol Ther. 2004;20:533–547
  13. Roberts CW, Nelson PL. Comparative analysis of prednisolone acetate suspensions. J Ocul Pharmacol Ther. 2007;23:182–187
  14. Simone JN, Whitacre MM. Effects of anti-inflammatory drugs following cataract extraction. Curr Opin Ophthalmol. 2001;12:63–67
  15. Perry HD, Donnenfeld ED. An update on the use of ophthalmic ketorolac tromethamine 0.4%. Expert Opin Pharmacother. 2006;7:99–107
  16. Saxby L, Rosen E, Boulton M. Lens epithelial cell proliferation, migration, and metaplasia following capsulorhexis. Br J Ophthalmol. 1998;82:945–952
  17. Sugita M, Kato S, Sugita G, Oshika T. Migration of lens epithelial cells through haptic root of single-piece acrylic-foldable intraocular lens. Am J Ophthalmol. 2004;137:377–379
  18. Aykan Ü, Bilge AH, Karadayi K, Akin T. The effect of capsulorhexis size on development of posterior capsule opacification: small (4.5 to 5.0 mm) versus large (6.0 to 7.0 mm). Eur J Ophthalmol. 2003;13:541–545
  19. Wejde G, Kugelberg M, Zetterström C. Position of anterior capsulorhexis and posterior capsule opacification. Acta Ophthalmol Scand. 2004;82:531–534
  20. Heatley CJ, Spalton DJ, Kumar A, et al. Comparison of posterior capsule opacification rates between hydrophilic and hydrophobic single-piece acrylic intraocular lenses. J Cataract Refract Surg. 2005;31:718–724
  21. Sundelin K, Shams H, Stenevi U. Three-year follow-up of posterior capsule opacification with two different silicone intraocular lenses. Acta Ophthalmol Scand. 2005;83:11–19
  22. Žemaitienė R, Jašinskas V, Barzdžiukas V, Auffarth GU. [Prevention of posterior capsule opacification using different intraocular lenses (results of one-year clinical study)]. [Lithuanian] Medicina (Kaunas). 2004;40:721–730
  23. Sacu S, Findl O, Menapace R, Buehl W. Influence of optic edge design, optic material, and haptic design on capsular bend configuration. J Cataract Refract Surg. 2005;31:1888–1894
  24. Werner L, Mamalis N, Izak AM, et al. Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses. J Cataract Refract Surg. 2005;31:805–811
  25. Buehl W, Menapace R, Sacu S, et al. Effect of a silicone intraocular lens with a sharp posterior optic edge on posterior capsule opacification. J Cataract Refract Surg. 2004;30:1661–1667

 No author has a financial or proprietary interest in any material or method mentioned.

 Allergan and Alcon supplied the clinic with samples of their respective products and provided postoperative surgical packs for all patients.

 The staff members and ophthalmic technicians at the Westfield Eye Center and nurses at the American Surgery Center provided assistance throughout the study period.

PII: S0886-3350(07)01385-5

doi: 10.1016/j.jcrs.2007.07.017

Journal of Cataract & Refractive Surgery
Volume 33, Issue 11 , Pages 1925-1929 , November 2007

Article Tools

* Image Usage & Resolution