Evaluation of the safety of prophylactic intracameral moxifloxacin in cataract surgery
Accepted 16 May 2008.
Purpose
To evaluate posterior and anterior segment safety of an intracameral injection of moxifloxacin 0.5% ophthalmic solution as prophylaxis for endophthalmitis in patients having cataract surgery.
Setting
Three private practices, the University of Minnesota School of Medicine, Stillwater, Minnesota, and the University of Cincinnati, Cincinnati, Ohio, USA.
Methods
In this prospective randomized combined-center open-label trial, 57 eyes of 47 patients were treated with intracameral moxifloxacin (250 μg/0.050 mL) or an equal volume of balanced salt solution at the conclusion of cataract surgery with intraocular lens implantation. Safety parameters, including visual acuity, intraocular pressure, endothelial cell counts, corneal pachymetry, corneal clarity and edema, and anterior chamber cells and flare, were evaluated preoperatively and for 3 months postoperatively.
Results
Optical coherence tomography results showed no statistically significant differences between the 2 treatment groups preoperatively or at 3 months. There were also no statistically significant differences between the 2 treatment groups in all other parameters preoperatively or at 1 day, 2 to 4 weeks, or 3 months. No study-related adverse events occurred.
Conclusion
There was no increased safety risk associated with a 250 μg/0.050 mL intracameral injection of moxifloxacin, which appears to be safe in the prophylaxis of endophthalmitis after cataract surgery.
From a private practice and the University of Minnesota School of Medicine (Lane), Stillwater, Minnesota; a private practice and the University of Cincinnati (Osher), Cincinnati, Ohio; UCLA Geffen School of Medicine (Masket), and a private practice (Masket, Belani), Los Angeles, California, USA
Corresponding author: Stephen S. Lane, MD, Associated Eye Care, 232 Main Street, Stillwater, Minnesota 55082, USA.
Drs. Lane, Osher, and Masket are consultants to Alcon Laboratories, Inc. Dr. Belani received a grant to support this research. Susanne Gardner was the medical writter, and Jenny Song provided the statistical analysis.
ABSTRACT