Journal of Cataract & Refractive Surgery
Volume 35, Issue 4 , Pages 637-642 , April 2009

Prophylactic intracameral cefazolin after cataract surgery: Endophthalmitis risk reduction and safety results in a 6-year study

Received 1 October 2008 ,Revised 23 December 2008 ,Accepted 23 December 2008.

References 

  1. Kresloff MS, Castellarin AA, Zarbin MA. Endophthalmitis. Surv Ophthalmol. 1998;43:193–218
  2. Eifrig CWG, Flynn HW, Scott IU, Newton J. Acute-onset postoperative endophthalmitis: review of incidence and visual outcomes (1995-2001). Ophthalmic Surg Lasers. 2002;33:373–378erratum 2003; 34:80
  3. Aaberg TM, Flynn HW, Schiffman J, Newton J. Nosocomial acute-onset postoperative endophthalmitis survey; a ten-year review of incidence and outcomes. Ophthalmology. 1998;105:1004–1010
  4. Mollan SP, Gao A, Lockwood A, Durrani OM, Butler L. Postcataract endophthalmitis: incidence and microbial isolates in a United Kingdom region from 1996 through 2004. J Cataract Refract Surg. 2007;33:265–268erratum, 759
  5. Montan PG, Wejde G, Koranyi G, Rylander M. Prophylactic intracameral cefuroxime; efficacy in preventing endophthalmitis after cataract surgery. J Cataract Refract Surg. 2002;28:977–981
  6. Montan PG, Wejde G, Setterquist H, Rylander M, Zetterstöm C. Prophylactic intracameral cefuroxime; evaluation of safety and kinetics in cataract surgery. J Cataract Refract Surg. 2002;28:982–987
  7. Garat M, Moser CL, Alonso-Tarrés C, Martín-Baranera M, Alberdi A. Intracameral cefazolin to prevent endophthalmitis in cataract surgery: 3-year retrospective study. J Cataract Refract Surg. 2005;31:2230–2234
  8. Barry P, Seal DV, Gettinby G, Lees F, Peterson M, Revie CW. ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery; preliminary report of principal results from a European multicenter study; the ESCRS Endophthalmitis Study Group. J Cataract Refract Surg. 2006;32:407–410
  9. Seal DV, Barry P, Gettinby G, Lees F, Peterson M, Revie CW, et al. ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery: case for a European multicenter study; the ESCRS Endophthalmitis Study Group. J Cataract Refract Surg. 2006;32:396–406
  10. ESCRS Endophthalmitis Study Group. Prophylaxis of postoperative endophthalmitis following cataract surgery: results of the ESCRS multicenter study and identification of risk factors. J Cataract Refract Surg. 2007;33:978–988
  11. Villada JR, Vicente U, Javaloy J, Alió JL. Severe anaphylactic reaction after intracameral antibiotic administration during cataract surgery. J Cataract Refract Surg. 2005;31:620–621
  12. National Committee for Clinical Laboratory Standards. Performance Standards for Antimicrobial Disk Susceptibility Tests: Approved Standard. NCCLS document M2-A7. 7th ed. Wayne, PA: National Committee for Clinical Laboratory Standards; 2002;
  13. Speaker MG, Menikoff JA. Prophylaxis of endophthalmitis with topical povidone–iodine. Ophthalmology. 1991;98:1769–1775
  14. Apt L, Isenberg S, Yoshimori R, Paez JH. Chemical preparation of the eye in ophthalmic surgery. III. Effect of povidone-iodine on the conjunctiva. Arch Ophthalmol. 1984;102:728–729
  15. Yu-Wai-Man P, Morgan SJ, Hildreth AJ, Steel DH, Allen D. Efficacy of intracameral and subconjunctival cefuroxime in preventing endophthalmitis after cataract surgery. J Cataract Refract Surg. 2008;34:447–451
  16. Vasavada AR, Gajjar D, Raj SM, Vasavada V, Vasavada V. Comparison of 2 moxifloxacin regimens for preoperative prophylaxis: prospective randomized triple-masked trial. Part 1: aqueous concentration of moxifloxacin. J Cataract Refract Surg. 2008;34:1379–1382
  17. Vasavada AR, Gajjar D, Raj SM, Vasavada V, Vasavada V. Comparison of 2 moxifloxacin regimens for preoperative prophylaxis: prospective randomized triple-masked trial. Part 2: residual conjunctival flora. J Cataract Refract Surg. 2008;34:1383–1388
  18. Espiritu CRG, Caparas VL, Bolinao JG. Safety of prophylactic intracameral moxifloxacin 0.5% ophthalmic solution in cataract surgery patients. J Cataract Refract Surg. 2007;33:63–68
  19. Arbisser LB. Safety of intracameral moxifloxacin for prophylaxis of endophthalmitis after cataract surgery. J Cataract Refract Surg. 2008;34:1114–1120
  20. Anand AR, Therese KL, Maldhavan HN. Spectrum of aetiological agents of postoperative endophthalmitis and antibiotic susceptibility of bacterial isolates. Indian J Ophthalmol. 2000;48:123–128Available from: http://www.ijo.in/text.asp?2000/48/2/123/14891Accessed December 31, 2008
  21. Petroutsos G, Savoldelli M, Pouliquen Y. Effect of cefazolin on the corneal endothelium; an experimental study. Ophthalmic Res. 1989;21:33–36
  22. Romero P, Méndez I, Salvat M, Fernández J, Almena M. Intracameral cefazolin as prophylaxis against endophthalmitis in cataract surgery. J Cataract Refract Surg. 2006;32:438–441
  23. Naseri A, Lietman TM. ASCRS survey of endophthalmitis prophylaxis. [letter] J Cataract Refract Surg. 2008;34:531–532

 No author has a financial or proprietary interest in any material or method mentioned.

PII: S0886-3350(09)00068-6

doi: 10.1016/j.jcrs.2008.12.023

Journal of Cataract & Refractive Surgery
Volume 35, Issue 4 , Pages 637-642 , April 2009