Journal of Cataract & Refractive Surgery
Volume 35, Issue 5 , Pages 912-916, May 2009

Cataract wound closure with a polymerizing liquid hydrogel ocular bandage

  • John A. Hovanesian, MD

      Affiliations

    • Corresponding Author InformationCorresponding author: John A. Hovanesian, MD, 24401 Calle De La Louisa, Suite 300, Laguna Hills, California 92653, USA.

From the Jules Stein Eye Institute, School of Medicine, University of California Los Angeles, Los Angeles, California, USA

Received 15 October 2008; received in revised form 30 December 2008; accepted 31 December 2008.

Purpose

To determine whether a polymerizing liquid hydrogel ocular bandage can create a watertight seal in a clear corneal cataract incision.

Setting

Laboratory.

Methods

Twenty-four clear corneal cataract wounds were made in eye-bank corneas. Twelve wounds were treated with a tissue-adherent hydrogel ocular bandage; 12 control wounds received no bandage. Each eye was tested under low-pressure conditions to detect fluid ingress of India ink on the eye's surface. Eyes were tested again with external compression to distort the wound to detect fluid egress.

Results

India ink did not enter the wound in any incision in the treated group but did enter 9 (75%) of 12 incisions in the control group. Fluid egress with external manipulation did not occur in any treated eyes but did occur in 11 (92%) control eyes.

Conclusion

A tissue-adherent hydrogel ocular bandage created a watertight seal in clear corneal cataract wounds.

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 Dr. Hovanesian is a consultant to I-Therapeutix.

 Presented at the annual meeting of the American Academy of Ophthalmology, Atlanta, Georgia, November 2008.

 Funded by a grant from I-Therapeutix, Waltham, Massachusetts, USA.

PII: S0886-3350(09)00104-7

doi:10.1016/j.jcrs.2008.12.036

Journal of Cataract & Refractive Surgery
Volume 35, Issue 5 , Pages 912-916, May 2009

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