Penetration of riboflavin and postoperative pain in corneal collagen crosslinking: Excimer laser superficial versus mechanical full-thickness epithelial removal
Received 23 February 2009; received in revised form 17 March 2009; accepted 18 March 2009.
Purpose
To compare the severity of postoperative pain and the rate of penetration of riboflavin between eyes treated by corneal crosslinking (CXL) using excimer laser superficial epithelial removal and mechanical full-thickness epithelial removal.
Setting
Departments of Ophthalmology, Ullevål University Hospital, Oslo, and University Hospital of Northern Norway, Tromsø, Norway.
Methods
Patients with corneal ectasia were treated with superficial corneal epithelial removal using the excimer laser programmed to 35 μm of phototherapeutic keratectomy (Group 1) or mechanical full-thickness epithelial removal with a brush (Group 2). Pain was evaluated postoperatively by the patients' subjective evaluation and need for analgesia. The duration of topical application of riboflavin to achieve stromal saturation was measured.
Results
Thirty eyes of 30 patients, 15 in each group, were treated. Postoperative pain was severe in 40.0% of patients in Group 1 and in no patient in Group 2 (P = .009) and moderate in 53.3% and 33.3%, respectively (no significant difference). The mean time to riboflavin saturation was 43.7 minutes ± 10.8 (SD) in Group 1 and 31.3 ± 3.0 minutes in Group 2 (P = .001).
Conclusion
Superficial epithelial removal using the excimer laser resulted in more postoperative pain and the need for prolonged application of riboflavin to achieve corneal saturation.
From the Departments of Ophthalmology, Oslo University Hospital Ullevål (Bakke, Drolsum), and University of Oslo, Oslo, and University Hospital of Northern Norway (Stojanovic, Chen), University of Tromsø, Tromsø, Norway
Corresponding author: Espen F. Bakke, MD, Department of Ophthalmology, Ullevål University Hospital, 0407 Oslo, Norway.
No author has a financial or proprietary interest in any material or method mentioned.
Presented in part at the Nordic Congress of Ophthalmology, Tromsø, Norway, June 2008.
ABSTRACT