Journal of Cataract & Refractive Surgery
Volume 36, Issue 9 , Pages 1499-1502 , September 2010

Aqueous penetration of moxifloxacin 0.5% ophthalmic solution and besifloxacin 0.6% ophthalmic suspension in cataract surgery patients

Received 6 February 2010 ,Revised 2 April 2010 ,Accepted 2 April 2010.

References 

  1. Herretes S, Stark WJ, Pirouzmanesh A, Reyes JMG, McDonnell PJ, Behrens A. Inflow of ocular surface fluid into the anterior chamber after phacoemulsification through sutureless corneal cataract wounds. Am J Ophthalmol. 2005;140:737–740
  2. Taban M, Sarayba MA, Ignacio TS, Behrens A, McDonnell PJ. Ingress of India ink into the anterior chamber through sutureless clear corneal cataract wounds. Arch Ophthalmol. 2005;123:643–648
  3. Taban M, Behrens A, Newcomb RL, Nobe MY, Saedi G, Sweet PM, et al. Acute endophthalmitis following cataract surgery; a systematic review of the literature. Arch Ophthalmol. 2005;123:613–620
  4. ESCRS Endophthalmitis Study Group. Prophylaxis of postoperative endophthalmitis following cataract surgery: results of the ESCRS multicenter study and identification of risk factors. J Cataract Refract Surg. 2007;33:978–988
  5. Barry P, Gardner S, Seal D, Gettinby G, Lees F, Peterson M, et al. Clinical observations associated with proven and unproven cases in the ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery; the ESCRS Endophthalmitis Study Group. J Cataract Refract Surg. 2009;35:1523–1531
  6. DeCroos FC, Afshari NA. Perioperative antibiotics and anti-inflammatory agents in cataract surgery. Curr Opin Ophthalmol. 2008;19:22–26
  7. Chang DF, Braga-Mele R, Mamalis N, Masket S, Miller KM, Nichamin LD, et al. Prophylaxis of postoperative endophthalmitis after cataract surgery; results of the 2007 ASCRS member survey; the ASCRS Cataract Clinical Committee. J Cataract Refract Surg. 2007;33:1801–1805
  8. Kim DH, Stark WJ, O'Brien TP, Dick JD. Aqueous penetration and biological activity of moxifloxacin 0.5% ophthalmic solution and gatifloxacin 0.3% solution in cataract surgery patients. Ophthalmology. 2005;112:1992–1996
  9. McCulley JP, Caudle D, Aronowicz JD, Shine WE. Fourth-generation fluoroquinolone penetration into the aqueous humor in humans. Ophthalmology. 2006;113:955–959
  10. Ong-Tone L. Aqueous humor penetration of gatifloxacin and moxifloxacin eyedrops given by different methods before cataract surgery. J Cataract Refract Surg. 2007;33:59–62
  11. Kim DH, Stark WJ, O'Brien TP. Ocular penetration of moxifloxacin 0.5% and gatifloxacin 0.3% ophthalmic solutions into the aqueous humor following topical administration prior to routine cataract surgery. Curr Med Res Opin. 2005;21:93–94
  12. Mah FS. Fourth-generation fluoroquinolones: new topical agents in the war on ocular bacterial infections. Curr Opin Ophthalmol. 2004;15:316–320
  13. Bertino JS. Impact of antibiotic resistance in the management of ocular infections: the role of current and future antibiotics. Clin Ophthalmol. 2009;3:507–521Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754082/pdf/opth-3-507.pdfAccessed May 16, 2010
  14. Shea KM. Nontherapeutic use of antimicrobial agents in animal agriculture: implications for pediatrics; American Academy of Pediatrics technical report. Pediatrics. 2004;114:862–910Available at: http://pediatrics.aappublications.org/cgi/reprint/114/3/862Accessed May 16, 2010
  15. Shea KM. Antibiotic resistance: what is the impact of agricultural uses of antibiotics on children's health?. Pediatrics. 2003;112:253–258Available at: http://pediatrics.aappublications.org/cgi/reprint/112/1/S1/253Accessed May 16, 2010
  16. Major JC, Engelbert M, Flynn HW, Miller D, Smiddy WE, Davis JL. Staphylococcus aureus endophthalmitis: antibiotic susceptibilities, methicillin resistance, and clinical outcomes. Am J Ophthalmol. 2010;149:278–283
  17. Yamada M, Yoshida J, Hatou S, Yoshida T, Minagawa Y. Mutations in the quinolone resistance determining region in Staphylococcus epidermidis recovered from conjunctiva and their association with susceptibility to various fluoroquinolones. Br J Ophthalmol. 2008;92:848–851
  18. Proksch JW, Granvil CP, Siou-Mermet R, Comstock TL, Paterno MR, Ward KW. Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans. J Ocul Pharm Ther. 2009;25:335–344

 Supported in part from an unrestricted research grant from Alcon Laboratories to Johns Hopkins University School of Medicine, Baltimore.

 Christina Ohnsman, MD, provided editorial assistance.

PII: S0886-3350(10)00859-X

doi: 10.1016/j.jcrs.2010.04.030

Journal of Cataract & Refractive Surgery
Volume 36, Issue 9 , Pages 1499-1502 , September 2010